Wednesday, July 1, 2009

Resveratrol Studies: Keeps estrogen from causing Breast Cancer (in test tubes)

Institute of Genetics and Molecular Biology have found that resveratrol, a natural compound found in the skin of red grapes and hence in red wine, may radically reduce the risk not only of heart disease but also of age related illnesses such as Alzheimer’s disease. It might also counter the effects of a high-fat diet and even prolong life.”

Research Resveratrol, a nutrient found in red wine, keeps estrogen from causing breast cancer in test-tube studies. Resveratrol increases production of an enzyme that destroys dangerous estrogen metabolites.

Resveratrol has the ability to prevent the first step that occurs when estrogen starts the process that leads to cancer. Scientists believe that this could stop the whole progression that leads to breast cancer down the road. This is dramatic because it was able to be done with fairly low concentrations of resveratrol.

Resveratrol is a natural phytolexin formed in the stem cells of the grapes and berries. It is formed in the response to attack by bacteria or fungi. It is the most potent anti inflammatory, anti cancer , and anti aging an agent discovered until date. Resveratrol is found in the skin of red grapes and is a constituent of red wine as well. A total amount of Resveratrol per serving of wine (a 5-ounce glass) for white wines is found to be between 0.01 to 0.27 mg.

It exists as two geometric isomers: cis (Z) and trans (E), with cis-isomer. The trans form can undergo isomerization to the cis form when exposed to ultraviolet irradiation.

Trans-resveratrol in the powder form was found to be stable under “accelerated stability” conditions of 75% humidity and 40 degrees C in the presence of air. Resveratrol content also stayed stable in the skins of grapes and pomace taken after fermentation and stored for a long period. All that means is that That resveratrol can have two forms of existence according to the subject.

The mechanisms of resveratrol’s apparent effects on life extension are not fully understood, but they appear to mimic several of the biochemical effects of calories restriction. A new report indicates that resveratrol activates Sirtuin 1 (SIRT1) and PGC-1a and improves functioning of the mitochondria. Another research calls into question the theory connecting resveratrol, SIRT1, and calorie restriction.

Resveratrol content interferes with all three stages of carcinogenesis” initiation, promotion and progression. Experiments in cell cultures of varied types and isolated sub cellular systems in vitro imply many mechanisms in the pharmacological activity of resveratrol.

Resveratrol content has other benefits as well. Resveratrol content was reported effective at neuronal cell dysfunction and cell death, and in theory could help against diseases such as Huntington’s disease and Alzheimer’s disease.

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